MSK-mediated phosphorylation of Histone 3 Ser28 couples MAPK signaling with early gene induction and cardiac hypertrophy
Emma Louise Robinson, Faye Drawnel, Saher Mehdi, Caroline R. Archer, Wei Liu, Hanneke Okkenhaug, Kanar Alkass, Jan Magnus Aronsen, Chandan K. Nagaraju, Ivar Sjaastad, Karin R. Sipido, Olaf Bergmann, J. Simon C. Arthur, Xin Wang, H. Llewelyn Roderick
The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.
bioRxiv · Jul 28, 2020 · PreprintMolecular Biology