H. Llewelyn Roderick

The paper identifies MGST1 as a key antioxidant gene in cardiac fibroblasts, showing its loss in heart failure increases oxidative stress and ferroptosis susceptibility.

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.

This study shows that Bcl-2 knockout in hiPSCs delays cardiomyocyte differentiation and reduces c-Myc expression, but not functionality in active areas.

The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.