The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.

Nature Cancer · Jan 9, 2026Peer-reviewedGenomics

Longitudinal multi-omic profiling uncovers immune escape and predictors of response in multiple myeloma

Denis J. Ohlstrom, William Pilcher, Marina E. Michaud, Chaitanya R. Acharya, Sarthak Satpathy, Edgar Gonzalez‐Kozlova, Reyka G. Jayasinghe, Katherine E. Ferguson, Hope Mumme, Shivani Nanda, Yizhe Song, Sowmitri Karthikeya Mantrala, Dimitra Karagkouni, Jessica Schulman, Nick Pabustan, , Manoj Bhasin

This study uses longitudinal multi-omic profiling to identify immune escape mechanisms and predictors of response in multiple myeloma.

bioRxiv · May 27, 2025 · PreprintCancer Biology

Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders

Sarah M. C. Colbert, Niamh Mullins, Grace Chan, Jacquelyn Leigh Meyers, Jessica Schulman, Samuel Kuperman C, Dongbing Lai, John I. Nürnberger, Martin Henry Plawecki, Chella Kamarajan, Andrey P. Anokhin, Kathleen Keenan Bucholz, VICTOR M. HESSELBROCK, Howard J. Edenberg, John Kramer, , Emma C. Johnson

The paper uses polygenic risk scores from GWAS to assess their association with suicidal thoughts and behaviors in a sample with alcohol use disorders, finding significant contributions from multiple PRS.

Complex Psychiatry · Jan 1, 2023Peer-reviewedGenetic & Genomic Medicine

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn Leigh Meyers, Jessica Schulman, John I. Nürnberger, Bernice Porjesz A, Yunlong Liu, The Collaborative Study on the Genetics of Alcoholism (COGA), VICTOR M. HESSELBROCK, Samuel Kuperman C, John R. Kramer, Chella Kamarajan, , Alison Goate

The paper integrates GWAS data with multi-omics datasets to identify novel genes for alcohol use disorder and link them to neurodegenerative diseases.

Nature Communications · Aug 20, 2021Peer-reviewedGenomics

Oncologic Therapy Shapes the Fitness Landscape of ClonalHematopoiesis

Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Zvi Braunstein, Sean M. Devlin, Daniel John Kelly, Minal A. Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine Callaghan Coombs, Nicole M. Caltabellotta, Mike Walsh, Kenneth Offit, Zsofia Kinga Stadler, , Elli Papaemmanuil

The paper shows oncologic therapy increases clonal hematopoiesis with DDR mutations, which predicts risk of therapy-related myeloid neoplasms.

bioRxiv · Nov 20, 2019 · PreprintGenetics