The paper uses polygenic risk scores from GWAS to assess their association with suicidal thoughts and behaviors in a sample with alcohol use disorders, finding significant contributions from multiple PRS.

Complex Psychiatry · Jan 1, 2023Peer-reviewedGenetic & Genomic Medicine

Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features

Chella Kamarajan, Ashwini Kumar Pandey, David Balin Chorlian, Jacquelyn Leigh Meyers, Sivan Kinreich, Gayathri Pandey, Stacey Saenz de Viteri, Jian Zhang, Weipeng Kuang, Peter B. Barr, Fazil Alıev, Andrey P. Anokhin, Martin Henry Plawecki, Samuel Kuperman C, Laura A. Almasy, , Bernice Porjesz A

This study uses machine learning to predict alcohol-related memory problems in older adults by integrating multi-domain features including brain connectivity, polygenic risk, and lifestyle factors.

bioRxiv · Dec 30, 2022 · PreprintNeuroscience

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

Dina Popova, Isabel Gameiro‐Ros, Mark M. Youssef, Petronio D. Zalamea, Ayeshia Morris, Iya Prytkova, Azadeh Jadali, Kelvin Y. Kwan, Chella Kamarajan, Jessica E. Salvatore, Xiaoling Xuei, David Balin Chorlian, Bernice Porjesz A, Samuel Kuperman C, Danielle M. Dick, , Ronald P. Hart

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

Molecular Psychiatry · Oct 7, 2022Peer-reviewedNeuroscience

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn Leigh Meyers, Jessica Schulman, John I. Nürnberger, Bernice Porjesz A, Yunlong Liu, The Collaborative Study on the Genetics of Alcoholism (COGA), VICTOR M. HESSELBROCK, Samuel Kuperman C, John R. Kramer, Chella Kamarajan, , Alison Goate

The paper integrates GWAS data with multi-omics datasets to identify novel genes for alcohol use disorder and link them to neurodegenerative diseases.

Nature Communications · Aug 20, 2021Peer-reviewedGenomics

Investigation of gene-environment interactions in relation to tic severity

Mohamed Abdulkadir, Dongmei Yu, Lisa Osiecki, Robert A. King, Thomas V. Fernandez, Lawrence W. Brown, Keun-Ah Anna Cheon, Barbara J. Coffey, Blanca García-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy J. Hedderly, Isobel Heyman, Hyun Ju Hong, , Pieter J. Hoekstra

The paper investigates gene-environment interactions related to tic severity by analyzing SNPs from GWASs of Tourette syndrome and related disorders in interaction with pre- and perinatal adversity.

Journal of Neural Transmission · Aug 13, 2021Peer-reviewedGenetic & Genomic Medicine

Impact of Binge Drinking During College on Resting State Functional Connectivity

Tien T. Tong, Jatin G. Vaidya, John Kramer, Samuel Kuperman C, Douglas R. Langbehn, Daniel S. OʼLeary

This study examines how different levels of binge drinking during college affect resting state functional connectivity over time, finding decreased connectivity in specific brain networks associated with attention and self-focused processes.

bioRxiv · Feb 9, 2021Neuroscience

Synaptic processes and immune-related pathways implicated in Tourette Syndrome

Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina Michelle Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten Müller‐Vahl, Manfred Stuhrmann, Yves Dion, Guy Armand Rouleau, Harald N. Aschauer, Mara Stamenkovic, , Harald Aschauer

This study identifies gene sets associated with Tourette Syndrome using genome-wide data, highlighting synaptic and immune-related pathways.

Translational Psychiatry · Jan 18, 2021Peer-reviewedGenetic & Genomic Medicine

Polygenic Prediction of Substance Use Disorders in Clinical and Population Samples

Peter B. Barr, Albert J. Ksinan, Jinni Su, Emma C. Johnson, Jacquelyn Leigh Meyers, Leah Flury Wetherill, Antti Latvala, Fazil Alıev, Grace Chan, Samuel Kuperman C, John I. Nürnberger, Chella Kamarajan, Andrey P. Anokhin, Arpana Agrawal A, Richard J. Rose, , Danielle M. Dick

This study uses polygenic risk scores to predict substance use disorders in two samples, finding increased risk with higher scores but limited clinical utility.

bioRxiv · Aug 30, 2019 · PreprintGenetics

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond Kenney Walters, Renato A Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams, Amy E. Adkins, Fazil Alıev, Silviu‐Alin Bacanu, Anthony J. Batzler, Sarah E. Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li‐Shiun Chen, Toni‐Kim Clarke, Yi‐Ling Chou, , Norbert Wodarz

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Nature Neuroscience · Nov 19, 2018Peer-reviewedGenetics