Danielle M. Dick

Genomic insights into substance use and disinhibitory disorders

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology

This study identifies genetic relationships between substance use disorders and externalizing/internalizing psychopathology, finding that internalizing contributes uniquely to SUD risk.

Trajectories of genetic risk across dimensions of alcohol use behaviors

This study examines how genetic risk scores for alcohol use behaviors change over time across multiple cohorts, finding varying associations with drinking patterns and trajectories.

Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights

This study identifies 77 genetic loci associated with suicidality through genome-wide association analyses across multiple cohorts and provides biological insights into its genetic architecture.

The Externalizing Spectrum and Suicide Risk: Insights from Genomics and Electronic Health Records in over 500,000 Veterans

This study identifies a genetic link between externalizing traits and suicide risk using genomic data and electronic health records from over 500,000 veterans.

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model

This study examines how polygenic risk scores for Alcohol Use Disorder affect microglial responses to ethanol exposure in human iPSC-derived microglia.

Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction

The paper uses GWEIS and in silico methods to study gene-environment interactions in alcohol misuse, identifying SES-modulated genes and highlighting challenges in detecting molecular GxE effects.

Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort

This study identifies correlates of risk for disinhibited behaviors in veterans using polygenic scores and electronic health records, finding strong associations with substance use disorders and related health outcomes.

Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics

This paper evaluates how down-sampling affects GWAS summary statistics and recommends reporting specific analyses to support their use.

A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders

This study uses Genomic Structural Equation Modeling to identify a common genetic factor underlying externalizing phenotypes and substance use disorders, finding that a single dimension of genetic risk best explains their relationships.

Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders

The paper uses polygenic risk scores from GWAS to assess their association with suicidal thoughts and behaviors in a sample with alcohol use disorders, finding significant contributions from multiple PRS.

Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features

This study uses machine learning to predict alcohol-related memory problems in older adults by integrating multi-domain features including brain connectivity, polygenic risk, and lifestyle factors.

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

The paper integrates GWAS data with multi-omics datasets to identify novel genes for alcohol use disorder and link them to neurodegenerative diseases.

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

This paper conducts a multivariate GWAS of AUDIT items to correct biases and identify novel genetic associations between alcohol consumption, misuse, and health outcomes.

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health

The paper uses multivariate genomic analysis of 1.5 million people to identify genetic loci related to addiction, antisocial behavior, and health, finding over 500 loci enriched for brain-expressed genes.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

Polygenic Prediction of Substance Use Disorders in Clinical and Population Samples

This study uses polygenic risk scores to predict substance use disorders in two samples, finding increased risk with higher scores but limited clinical utility.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

Polygenic prediction of the phenome, across ancestry, in emerging adulthood

The paper constructs a polygenic risk atlas for 33 traits in emerging adults and finds genetic risks for schizophrenia, neuroticism, and depression predict various phenotypes.