A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
Wouter J. Venema, Sanne Hiddingh, Jorg van Loosdregt, John Bowes, Brunilda Balliu, Joke Helena de Boer, Jeanette Ossewaarde-van Norel, Susan D. Thompson, Carl D. Langefeld, Lars T. van der Veken, Konstantinos Sofiadis, Peter H.L. Krijger, Wouter L. de Laat, Jonas J. W. Kuiper
The paper identifies causal SNPs near ERAP2 that regulate its expression through long-range chromatin interactions, linking autoimmune disease risk variants to enhancer activity.
bioRxiv · Mar 3, 2023 · PreprintGenomics