Author

Sanne Hiddingh

University Medical Center UtrechtORCID 0000-0003-1937-374XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Jonas J. W. KuiperiD· 4 shared Joke Helena de BoeriD· 3 shared Timothy R. D. J. RadstakeiD· 3 shared Anneke I. den HollanderiD· 2 shared Roel A. OphoffiD· 2 shared Sara L. PulitiD· 2 shared Alejandro Fonollosa· 1 shared Alfredo AdániD· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersGenetics

Jonas J. W. KuiperORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 3, 2023

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

Wouter J. Venema, Sanne Hiddingh, Jorg van Loosdregt…·Jonas J. W. Kuiper

The paper identifies causal SNPs near ERAP2 that regulate its expression through long-range chromatin interactions, linking autoimmune disease risk variants to enhancer activity.

3 citations

humanDNA methylation

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GeneticsHuman Molecular GeneticsPeer-reviewedSep 10, 2018

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.

Jonas J. W. Kuiper, Jessica van Setten, Matthew A.M. Devall…·Timothy R. D. J. Radstake

This study identifies functionally distinct ERAP1 and ERAP2 haplotypes associated with Birdshot Uveitis and shows their combined effect enhances disease risk.

57 citations

humanstatistical model

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Molecular BiologybioRxivPreprintJan 8, 2018

mTOR complex 1 pathway activation in severe keratoconus; the functional implications of GWAS identified loci.

Robert P. L. Wisse, Jonas J. W. Kuiper, Gijsbert M de Veij Mestdagh…·Jasper C. A. Broen

The paper identifies up-regulation of the mTORC1 pathway in keratoconus corneas and confirms differential expression of GWAS risk loci.

DOI 10.1101/244897

humanbulk RNA-seq

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GeneticsbioRxivPreprintAug 14, 2017

An Amino Acid Motif In HLA-DRB1 Distinguishes Patients With Uveitis In Juvenile Idiopathic Arthritis

Anne‐Mieke J. W. Haasnoot, MW Schilham, Sylvia S M Kamphuis…·Jonas J. W. Kuiper

The paper identifies serine-11 in HLA-DRB1 as a risk factor for uveitis in JIA, showing sex-specific association and peptide-binding preferences.

1 citation

humanGWAS summary statistics

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