Peter H.L. Krijger

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

The paper identifies causal SNPs near ERAP2 that regulate its expression through long-range chromatin interactions, linking autoimmune disease risk variants to enhancer activity.

Detailed in vivo characterization of the players and impact of individual loop extrusion trajectories

This study uses TACL to analyze individual cohesin loop extrusion trajectories in vivo, revealing new roles for cohesin subunits and their interactions with CTCF and chromatin structure.

Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes

This study shows enhancers recruit cohesin to form chromatin domains, engage CTCF sites, and activate distant genes, with transcription factors and mediator required for all distances but cohesin specifically for long-range activation.

Implication of the cellular factor CTCF in the regulation of Bovine Leukemia Virus latency and tridimensional chromatin organization

This study shows CTCF regulates BLV transcription and 3D chromatin structure, affecting viral latency and host cell organization.

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.