Author

Si Liu

BGI Group (China)ORCID 0000-0002-5795-0782Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Si Liu1 paper · Fred Hutch Cancer Center

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Bing XiaoiD· 1 shared Changjun ZhangiD· 1 shared Chaochao Chai· 1 shared Chen LiiD· 1 shared Danyu Y. LiniD· 1 shared Dongsheng CheniD· 1 shared Fang CheniD· 1 shared Fang HaniD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Bing XiaoORCID

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3 papers

Recent·Most cited

A computational method for Cell type-specific Expression Quantitative Trait Loci mapping using bulk RNA-seq data

Paul Little, Si Liu, Vasyl Zhabotynsky, Yun Li, Danyu Y. Lin, Wei Sun

This paper introduces a statistical method to map cell type-specific eQTLs using bulk RNA-seq data, improving accuracy over existing methods by leveraging allele-specific expression.

bioRxiv · Mar 31, 2022 · PreprintGenomics

Individual Level Differential Expression Analysis for Single Cell RNA-seq data

Mengqi Zhang, Si Liu, Zhen Miao, Fang Han, Raphaël Gottardo, Wei Sun

The paper introduces IDEAS, a method for differential expression analysis in scRNA-seq data at the individual level, finding neurogranin-expressing neurons and ERBB signals in microglia are associated with autism.

Genome biology · Jan 24, 2022Peer-reviewedBioinformatics

Single cell atlas of trisomy 21 cerebral cortex

Jingxuan Zhang, Shiyou Wang, Zaoxu Xu, Xiangning Ding, Chen Li, Yonghong Zhang, Yin Chen, Jixing Zhong, Langchao Liang, Chaochao Chai, Xiaoling Wang, Rong Xiang, Jiacheng Zhu, Xiumei Lin, Peiwen Ding, , Xun Xu

This study creates the first single cell atlas of T21 cerebral cortex, identifying dysregulated genes and developing a platform for data exploration.

bioRxiv · Jan 1, 2020 · PreprintNeuroscience