Vasyl Zhabotynsky

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.

This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

This paper introduces a statistical method to map cell type-specific eQTLs using bulk RNA-seq data, improving accuracy over existing methods by leveraging allele-specific expression.

The paper develops TReCASE, a statistical method for eQTL mapping using ASE data, showing it improves power and efficiency compared to existing methods.

The paper uses Bayesian modeling to analyze XCI skew in genetically diverse mice, identifying a novel Xce allele linked to copy number changes.

This study identifies genetic factors influencing antipsychotic-induced adverse reactions in mice using RIX lines, finding strong strain and treatment interactions for behavioral phenotypes.