Proximity-induced protein deglycosylation by endogenous O-GlcNAcase
Haixing Xu, Bowen Ma, Yunpeng Huang, Wai‐Lung Ng
This paper introduces DOGTACs, a method to selectively remove O-GlcNAc from target proteins using endogenous OGA in living cells, showing concentration- and time-dependent de-O-GlcNAcylation without affecting global O-GlcNAc levels.
bioRxiv · Aug 26, 2026 · PreprintCell Biology