Wai‐Lung Ng

This paper introduces DOGTACs, a method to selectively remove O-GlcNAc from target proteins using endogenous OGA in living cells, showing concentration- and time-dependent de-O-GlcNAcylation without affecting global O-GlcNAc levels.

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.