NeuroscienceSciencePeer-reviewed
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Gerard Crowley, Minjung Kim, Nathanael O’Neill…·Soyon Youngae Hong
This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.
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