Soyon Youngae Hong

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models

This study identifies astrocyte-derived MFG-E8 as a key mediator of microglial synapse elimination in Alzheimer's disease mouse models, showing its role in synapse loss and potential as a therapeutic target.

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons

The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.

Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimers Disease Models

This study identifies SPP1 as a key mediator of microglial synaptic engulfment in Alzheimer's disease models, showing its role in neuroimmune interactions.

Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer's Disease Models

Microglia selectively engulf synapses in Alzheimer-like mouse brains via PtdSer-TREM2 signaling.

Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.