Nathanael O’Neill

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

An adaptable, reusable, and light implant for chronic Neuropixels probes

The paper introduces an adaptable implant for chronic Neuropixels recordings in mice, enabling stable, reusable, and lightweight neural recordings across multiple experimental conditions.

Developmental instability of CA1 pyramidal cells in Dravet Syndrome

This study investigates how loss of Scn1a affects CA1 pyramidal cell development and homeostatic plasticity in a Dravet Syndrome model before seizures occur.

Extracellular GABA waves regulate coincidence detection in excitatory circuits

The paper shows that extracellular GABA concentration modulates coincidence detection in excitatory circuits by affecting membrane shunting via GAT-1.

Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts

The paper investigates how TNF and IL1β cytokines affect potassium channel expression in rat synovial fibroblasts, finding increased Kcnma1 and Kcnmb3 gene expression.