Author
VIB-KU Leuven Center for Brain & Disease ResearchORCID 0000-0001-9233-972XUnclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Gerard Crowley, Minjung Kim, Nathanael O’Neill…·Soyon Youngae Hong
This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.
Lutgarde Serneels, Annerieke S. R. Sierksma, Emanuela Pasciuto…·Bart De Strooper
The paper develops a new mouse model for human microglia transplantation to study neurodegenerative diseases and makes it publicly available.
Rafaela Policarpo, Leen Wolfs, Saúl Martínez‐Montero…·Constantin van Outryve d’Ydewalle
This study investigates the role of MAPT-AS1 in regulating Tau expression in human neurons and finds no evidence supporting its function as described in Simone et al.
Sriram Balusu, Katrien Horré, Nicola Thrupp…·Bart De Strooper
The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.
Annerieke S. R. Sierksma, Ashley Lu, Renzo Mancuso…·Mark W. E. J. Fiers
The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.
Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli…·Bart De Strooper
The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.