Author

Jacob C. Massey

ORCID 0000-0002-0165-4618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph MagagnoliiD· 1 shared Michael D. WyattiD· 1 shared Phillip BuckhaultsiD· 1 shared S. Scott SuttoniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperPharmacology & Toxicology

Joseph MagagnoliORCID

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1 paper

Recent·Most cited

Collateral damage of NUDT15 deficiency in cancer provides a cancer pharmacogenetic therapeutic window with thiopurines

Jacob C. Massey, Joseph Magagnoli, S. Scott Sutton, Phillip Buckhaults, Michael D. Wyatt

The paper identifies that NUDT15 loss in cancer cells creates a therapeutic window for thiopurines, showing increased sensitivity in cancer cell lines and reduced prostate cancer incidence with thiopurine and xanthine oxidase inhibitor co-treatment.

bioRxiv · Apr 8, 2024 · PreprintPharmacology & Toxicology