Phillip Buckhaults

StarTrace is a drug testing platform using patient-derived organoid avatars to rank drug responses and guide personalized therapy by multiplexing organoids with clonal barcoding.

The paper identifies NXPE1 as a gene responsible for sialic acid O-acetylation in the human colon, linking it to mPAS staining differences through genetic and functional analyses.

This study identifies gene knockouts in DNA repair pathways that re-sensitize TP53-null colon cancer organoids to cisplatin treatment.

The paper identifies that NUDT15 loss in cancer cells creates a therapeutic window for thiopurines, showing increased sensitivity in cancer cell lines and reduced prostate cancer incidence with thiopurine and xanthine oxidase inhibitor co-treatment.