S. Scott Sutton

AI-based mining of biomedical literature: Applications for drug repurposing for the treatment of dementia

This paper introduces AGATHA, an AI tool for drug repurposing in dementia by analyzing biomedical literature and identifying gene-disease associations using statistical methods.

Collateral damage of NUDT15 deficiency in cancer provides a cancer pharmacogenetic therapeutic window with thiopurines

The paper identifies that NUDT15 loss in cancer cells creates a therapeutic window for thiopurines, showing increased sensitivity in cancer cell lines and reduced prostate cancer incidence with thiopurine and xanthine oxidase inhibitor co-treatment.