Author

Maria Derakhshan

London School of Hygiene & Tropical MedicineORCID 0000-0002-0167-0060Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:database / resource· 2

Frequent Co-Authors

Andrew M. PrenticeiD· 4 shared Matt J. SilveriD· 4 shared Noah J. KessleriD· 3 shared Prachand IssarapuiD· 3 shared Sophie E. MooreiD· 3 shared Caroline H. D. FalliD· 2 shared Garrett HellenthaliD· 2 shared Giriraj R. ChandakiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenomics

Andrew M. PrenticeORCID

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4 papers

Recent·Most cited

KZFP-mediated variable DNA methylation of a primate-specific transposon is linked to type I diabetes in humans

Maria Derakhshan, Prachand Issarapu, Andrew M. Prentice, Julius A Kuebel, Sophie E. Moore, Robin M. Bernstein, Abdul Karim Sesay, Mariama Jammeh, Robert A. Waterland, Garrett Hellenthal, Michaël Imbeault, Matt J. Silver

The paper links KZFP-mediated DNA methylation of a primate-specific transposon to type 1 diabetes risk through genetic and epigenetic analyses.

medRxiv · Apr 22, 2025 · PreprintGenetic & Genomic Medicine

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj Singh Nongmaithem, Alagu Sankareswaran S., Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail Rafik Mansuri, Maria Derakhshan, Ghattu V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, , Stephen Owens

This study identifies DNA methylation at the SOCS3 gene as a factor influencing child height in low and middle-income countries, with a causal effect confirmed by Mendelian randomization.

Nature Communications · Aug 25, 2023Peer-reviewedGenomics

Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

Maria Derakhshan, Noah J. Kessler, Miho Ishida, Charalambos Demetriou, Nicolas Brucato, Gudrun E. Moore, Caroline H. D. Fall, Giriraj R. Chandak, François‐Xavier Ricaut, Andrew M. Prentice, Garrett Hellenthal, Matt J. Silver

The paper identifies hypervariable DNA methylation sites across multiple tissues and ethnicities, showing they are influenced by environmental factors and established early in human development.

Nucleic Acids Research · Jun 17, 2022Peer-reviewedGenomics

Environmentally sensitive hotspots in the methylome of the early human embryo

Matt J. Silver, Ayden Saffari, Noah J. Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E. Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M. Prentice

The paper identifies CpGs in the early human embryo methylome associated with season of conception, showing environmental influences on DNA methylation.

eLife · Feb 21, 2022Peer-reviewedGenomics