Author

Noah J. Kessler

University of CambridgeORCID 0000-0002-2740-6663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 5 Approach:statistical model· 5 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:database / resource· 2 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew M. PrenticeiD· 3 shared Maria DerakhshaniD· 3 shared Matt J. SilveriD· 3 shared Amir D. HayiD· 2 shared Anne C. Ferguson‐SmithiD· 2 shared Caroline H. D. FalliD· 2 shared Giriraj R. ChandakiD· 2 shared Modupeh BettsiD· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Andrew M. PrenticeORCID

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5 papers

Recent·Most cited

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj Singh Nongmaithem, Alagu Sankareswaran S., Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail Rafik Mansuri, Maria Derakhshan, Ghattu V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, , Stephen Owens

This study identifies DNA methylation at the SOCS3 gene as a factor influencing child height in low and middle-income countries, with a causal effect confirmed by Mendelian randomization.

Nature Communications · Aug 25, 2023Peer-reviewedGenomics

Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise

Amir D. Hay, Noah J. Kessler, Daniel Gebert, Nozomi Takahashi, Hugo Tavares, Felipe Karam Teixeira, Anne C. Ferguson‐Smith

The paper measures mitotic DNA methylation inheritance at single CpG sites and finds that intermediate methylation is imprecise due to DNMT1 activity, challenging the stability of DNA methylation as an epigenetic mark.

bioRxiv · Jan 27, 2023 · PreprintGenetics

Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

Maria Derakhshan, Noah J. Kessler, Miho Ishida, Charalambos Demetriou, Nicolas Brucato, Gudrun E. Moore, Caroline H. D. Fall, Giriraj R. Chandak, François‐Xavier Ricaut, Andrew M. Prentice, Garrett Hellenthal, Matt J. Silver

The paper identifies hypervariable DNA methylation sites across multiple tissues and ethnicities, showing they are influenced by environmental factors and established early in human development.

Nucleic Acids Research · Jun 17, 2022Peer-reviewedGenomics

Environmentally sensitive hotspots in the methylome of the early human embryo

Matt J. Silver, Ayden Saffari, Noah J. Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E. Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M. Prentice

The paper identifies CpGs in the early human embryo methylome associated with season of conception, showing environmental influences on DNA methylation.

eLife · Feb 21, 2022Peer-reviewedGenomics

Genomic properties of variably methylated retrotransposons in mouse

Jessica L. Elmer, Amir D. Hay, Noah J. Kessler, Tessa M. Bertozzi, Eve A. C. Ainscough, Anne C. Ferguson‐Smith

The paper identifies and characterizes variably methylated retrotransposons in mice, showing their potential for long-range regulation and inter-individual transcriptional variability.

Mobile DNA · Feb 21, 2021Peer-reviewedGenetics