The paper shows that imputing DNA methylation loci from epigenome-wide data provides stronger associations with smoking and age than directly measured CpGs.

bioRxiv · Sep 5, 2024 · PreprintGenetics

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj Singh Nongmaithem, Alagu Sankareswaran S., Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail Rafik Mansuri, Maria Derakhshan, Ghattu V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, , Stephen Owens

This study identifies DNA methylation at the SOCS3 gene as a factor influencing child height in low and middle-income countries, with a causal effect confirmed by Mendelian randomization.

Nature Communications · Aug 25, 2023Peer-reviewedGenomics

Characterizing the human methylome across the life course: findings from eight UK-based studies

Esther Walton, Riccardo Emilio Marioni, Hannah R. Elliott, Simon R Cox, Ian J. Deary, Alun David Hughes, Therese Tillin, Meena Kumari B, Tom Woofenden, Juan Castillo Fernandez, Jordana T. Bell, Alissa T. Goodman, George B. Ploubidis, Kate M. Tilling, Matthew J Suderman, , Caroline Laura Relton

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

bioRxiv · Sep 18, 2021 · PreprintGenetics

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

Josine L. Min, Gibran Hemani, Eilis J. Hannon, Koen F. Dekkers, Juan Castillo Fernandez, René Luijk, Elena Carnero‐Montoro, Daniel John Lawson, Kimberley Burrows, Matthew J Suderman, Andrew D. Bretherick, Tom G. Richardson, Johanna Klughammer, Valentina Iotchkova, Gemma C. Sharp, , Marinus H. van IJzendoorn

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Nature Genetics · Sep 1, 2021Peer-reviewedGenetic & Genomic Medicine

Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer

Carolina Bonilla, Bernardo Bertoni, Josine L. Min, Gibran Hemani, Hannah R. Elliott

This study investigates DNA methylation as a mediator between pigmentation genes, traits, and skin cancer using GWAS and epigenetic data from European populations.

Pigment Cell & Melanoma Research · Nov 28, 2020Peer-reviewedGenetics

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

Daniel L. McCartney, Josine L. Min, Rebecca Claire Richmond, Ake Tzu-Hui Lu, Maria Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Şeyma Katrinli, Pei‐Lun Kuo, Pamela R. Matías‐García, Pashupati Prasad Mishra, , Jerome I. Rotter

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

bioRxiv · Jun 29, 2020 · PreprintGenetics

DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

Matt J. Barter, Catherine Bui, Kathleen Cheung, Julia Falk, Rodolfo Gómez, Andrew J. Skelton, Hannah R. Elliott, Louise N. Reynard, David Alan Young

The paper identifies DNA hypomethylation during MSC chondrogenesis, particularly at enhancer regions, and links these changes to the chondrocyte phenotype and cartilage disease.

Scientific Reports · Jan 24, 2020Peer-reviewedGenomics

PGP-UK: a research and citizen science hybrid project in support of personalized medicine

Stephan Beck, Alison Berner, Graham R. Bignell, Maggie Bond, M Callanan, Olga Chervova, Lucía Conde, Manuel Corpas, Simone Ecker, Hannah R. Elliott, Silvana A. Fioramonti, Adrienne Margaret Flanagan, Ricarda Gaentzsch, David G. Graham, Deirdre Gribbin, , John N. Wood

PGP-UK explores citizen science in genomics by recruiting participants, sharing data, and developing tools to advance personalized medicine.

BMC Medical Genomics · Nov 27, 2018Peer-reviewedGenomics