Takahiro K Fujiwara

This paper develops a single-molecule tracking method to assess ligand-binding ability of full-length β2AR without purification, revealing how detergent microenvironments affect protein stability and function.

The paper uses single-molecule imaging to study opioid receptor heterodimerization and shows that blocking MOR-DOR heterodimers reduces morphine tolerance in mice.

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

This study shows SynGAP forms condensates at low concentrations and recruits PSD95 and receptor oligomers, suggesting it initiates PSD formation.

The paper discovers a new form of cell-cell communication called DIVE, where vesicles are directly transferred between adjacent cells, potentially enabling nucleic acid exchange and phenotypic synchronization.

The paper examines surface dynamics of TrkA and p75NTR receptors in AD neurons and finds altered diffusion rates in AD patients compared to healthy controls.

This study uses live-cell single-molecule imaging to show that estradiol rapidly and dose-dependently alters AMPAR surface movement in neurons, with effects varying between somas and neurites.