Yiqiu Zhang

The paper identifies and characterizes a fourth type VI secretion system (H4-T6SS) in Pseudomonas aeruginosa, showing it is repressor-gated and contributes to inter- and intraspecific antagonism.

OPUS-DSD2 disentangles structural heterogeneity in cryo-EM and cryo-ET data by separating rigid-body dynamics from other variations, improving analysis of macromolecular structures.

OPUS-Design improves protein sequence design by combining 3DCNN and protein language models, achieving high sequence recovery rates and successfully designing a thermal-tolerant mutant of T4 lysozyme.