Tao Dong

This paper develops a modular antimicrobial platform using engineered SimCells and mini-SimCells to selectively eliminate E. coli with high specificity and efficiency.

The paper identifies and characterizes a fourth type VI secretion system (H4-T6SS) in Pseudomonas aeruginosa, showing it is repressor-gated and contributes to inter- and intraspecific antagonism.

This paper identifies TseP as a dual amidase-lysozyme T6SS effector with potential for combating antimicrobial resistance.

The paper develops a method to deliver active Cre recombinase and exogenous effectors using engineered type six secretion systems, enabling genetic editing without DNA introduction.