Benchmarking single-cell foundation models for real-world RNA-seq data integration
Siyu Han, Tamas Ryszard Sztanka-Toth, Enes Senel, Ahmed Elnaggar, Jaymala Patel, Tommaso Mansi, Denis A. Smirnov, Joel Greshock, Alex Javidi
This study benchmarks single-cell foundation models for data integration using real-world RNA-seq data and finds that fine-tuned scGPT_CP performs best in technical correction while scVI is the top overall performer.
bioRxiv · Apr 21, 2026 · PreprintBioinformatics