AAV2 Bypasses Direct Endosomal Escape by Using AAVR to Access the Trans-Golgi Network en Route to the Nucleus.
Marti Cabanes‐Creus, Sophia H.Y. Liao, Marta Pardo-Piñón, Adriana Lucely Rojas, Joseph M. Kelich, Jackson Coyne, Maddison Knight, Deborah Nazareth, Ramon Roca-Pinilla, Sujata Senapati, Matthew C. Walsh, Pedro Joel Cejas, Sean M. Armour, Aitor Hierro, Leszek Lisowski
This study shows AAV2 bypasses endosomal escape by using AAVR to access the trans-Golgi network, challenging the model of direct endosomal escape.
Journal of Virology · Jul 29, 2026Peer-reviewedCell Biology