Aitor Hierro

This study shows AAV2 bypasses endosomal escape by using AAVR to access the trans-Golgi network, challenging the model of direct endosomal escape.

The paper identifies SNX12 as a retromer adaptor critical for HPV16 infection and shows how cargo-adaptor interactions specify retromer coat architecture through structural and functional analyses.

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.

The paper identifies two Fam21 fragments interacting with VPS35 and a third interacting with VPS29, revealing distinct binding modes and structural insights into retromer-WASH complex recruitment.