Author

Lisardo Boscá

Instituto de Salud Carlos IIIORCID 0000-0002-0253-5469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adrián Povo‐RetanaiD· 1 shared Anirban ChakrabortyiD· 1 shared Balaji KrishnaniD· 1 shared Fred H. GageiD· 1 shared Gourisankar GhoshiD· 1 shared Jérôme MertensiD· 1 shared Johannes C. M. SchlachetzkiiD· 1 shared Joseph R. HerdyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Adrián Povo‐RetanaORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

A Toxic Tau-PFKFB3 Circuit Reduces F2,6BP Levels and Drives Neurodegeneration

Santi M Mandal, Anirban Chakraborty, Shandy Shahabi, Mikita Mankevich, Adrián Povo‐Retana, Tapan Biswas, Sergio Sánchez‐García, Sravan Gopalkrishnashetty Sreenivasmurthy, Lucia Zhou Yang, Joseph R. Herdy, Jérôme Mertens, Fred H. Gage, Johannes C. M. Schlachetzki, Balaji Krishnan, Lisardo Boscá, , Gourisankar Ghosh

This paper identifies the PFKFB3-F2,6BP metabolic axis as a key driver of Alzheimer's disease by linking metabolic dysregulation to genomic stability and Tau proteostasis, showing that F2,6BP supplementation rescues AD phenotypes across multiple models.

bioRxiv · May 31, 2026 · PreprintNeuroscience