Johannes C. M. Schlachetzki

Cell type-specific histone acetylation landscape in Alzheimer's disease reveals a putative role of MITF in microglia

This study identifies cell-type-specific histone acetylation changes in Alzheimer's disease, highlighting MITF's potential role in microglial dysfunction.

A Toxic Tau-PFKFB3 Circuit Reduces F2,6BP Levels and Drives Neurodegeneration

This paper identifies the PFKFB3-F2,6BP metabolic axis as a key driver of Alzheimer's disease by linking metabolic dysregulation to genomic stability and Tau proteostasis, showing that F2,6BP supplementation rescues AD phenotypes across multiple models.

Cannabis Use by People with HIV is Associated with an Anti-Inflammatory Immunometabolic Phenotype in Monocyte-Derived Macrophages

This study finds that daily cannabis use in people with HIV is linked to an anti-inflammatory immunometabolic phenotype in macrophages, associated with reduced neurocognitive deficits.

Csf1r-mediated depletion of midbrain microglia prevents dopaminergic neuron loss during chronic colitis

Somatic mutations in ALS genes in the motor cortex of sporadic ALS patients

This study identifies somatic mutations in ALS genes in the motor cortex of sporadic ALS patients, particularly in excitatory neurons, suggesting a role in disease initiation.

Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes

The paper examines sex differences in the epigenomic landscape of human dorsal root ganglia, identifying sex-specific chromatin accessibility and transcription factor binding patterns associated with nociceptive gene regulation.

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIV

This study shows dopamine increases IL-1β in myeloid cells via differential dopamine receptor expression, and this effect is exacerbated by HIV.

Direct and indirect regulation of β- glucocerebrosidase by the transcription factors USF2 and ONECUT2

The paper identifies transcription factors that regulate β-glucocerebrosidase activity, showing that USF2 and ONECUT2 have opposing effects on GCase levels and function.

Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain

The paper uses mosaic variant barcodes to analyze clonal dynamics in human forebrain cell types, revealing lineage relationships and clonal spread patterns.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

Interleukin-33 coordinates a microglial phagocytic response and limits corticothalamic excitability and seizure susceptibility

This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.

Gene regulatory networks underlying human microglia maturation

This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.

Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.

CXCR4 involvement in neurodegenerative diseases

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

Immune-related genetic enrichment in frontotemporal dementia

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.