Xiaoguang Dai

This study examines genome evolution in parthenogenetic nematodes, revealing chromosome fusions, rearrangements, and evidence of rare sexual reproduction events.

CRISPore-seq combines CRISPR perturbations with long-read transcriptomics to detect alternative splicing changes, revealing that exon skipping is common and linked to RNA-binding protein perturbations.

This study introduces Telo-seq, a method using long-read sequencing to measure telomere lengths with high resolution, revealing dynamics in aging and cancer.

The paper uses long-read RNA-seq data to identify new transcripts and develop a tool to analyze genetic effects on transcript structure, revealing insights into splicing regulation and variant interpretation.

Pore-C reads multi-way chromatin contacts directly off unamplified Nanopore long reads, recovering Hi-C-scale features while also resolving rearranged cancer alleles and supporting de novo assembly.

WIMP enables rapid, real-time species identification in complex samples using MinION sequencing and bioinformatics tools within 3.5 hours.

This study uses MinION sequencing to assemble complete genomes of previously uncultured environmental bacteria, enabling genomic analysis and comparison.