Author

Aniek Martens

Radboud University Medical CenterORCID 0000-0002-0291-0281Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

Claudia KutteriD· 1 shared Erik de VriezeiD· 1 shared Erwin van WijkiD· 1 shared Gert Jan C. VeenstraiD· 1 shared Hannah K. NeikesiD· 1 shared Hannie KremeriD· 1 shared Jaap OostrikiD· 1 shared Jolien PeijnenborgiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperMolecular Biology

Claudia KutterORCID

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3 papers

Recent·Most cited

ONECUT2 restricts Microfold cell numbers in the small intestine; a multi-omics study

Maria V. Luna Velez, Hannah K. Neikes, Rebecca R. Snabel, Yarah M. Quint, Qian Chen, Aniek Martens, Gert Jan C. Veenstra, Michael R. Freeman, Simon J. van Heeringen, Michiel Vermeulen

This study uses multi-omics to show ONECUT2 restricts M cell differentiation in mouse intestinal organoids by acting downstream of RANK/RANKL signaling.

Nucleic Acids Research · Dec 14, 2022Peer-reviewedMolecular Biology

CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells

Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma Pareja Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter

This study investigates on-target genomic effects of CRISPR/Cas9 deletions in human cells, revealing functional DNA disruptions and unexpected consequences.

Genome Research · Sep 30, 2022Peer-reviewedMolecular Biology

Allele-specific antisense oligonucleotide therapy for dominantly inherited hearing impairment DFNA9.

Erik de Vrieze, Jolien Peijnenborg, Jorge Cañas-Martín, Aniek Martens, Jaap Oostrik, Simone van den Heuvel, Kornelia Neveling, Ronald J. E. Pennings, Hannie Kremer, Erwin van Wijk

This study demonstrates that antisense oligonucleotides targeting the c.151C>T mutation in COCH can reduce mutant transcript levels in transgenic cells, suggesting potential as a therapy for DFNA9.

bioRxiv · Sep 29, 2020 · PreprintGenetics