Rebecca R. Snabel

This study identifies Neuromedin-U (NMU) and Endothelin-1 (ET-1) as key signaling factors influencing cardiomyocyte differentiation and electrophysiology in human cardiac organoids.

DANSE models time-series multi-omics data to identify key transcription factors driving biological processes, using iPSC differentiation datasets as examples.

The paper compares cardiac differentiation trajectories in different culture conditions and identifies ZNF711 as a regulator of cardiomyocyte commitment and lineage balance.

This study uses multi-omics to show ONECUT2 restricts M cell differentiation in mouse intestinal organoids by acting downstream of RANK/RANKL signaling.