Claudia Kutter

tTEscanR: A user-friendly integrative R package for quantifying and visualizing translation efficiency from sequencing data in diverse biological systems

tTEscanR quantifies and visualizes translation efficiency from transcriptomic data across diverse biological systems, revealing translational regulatory programs in cancer, aging, and neurodegeneration.

Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer

The paper identifies key RBP regulatory interactions in liver cancer and suggests potential drug candidates through GRN analysis and enrichment studies.

Estrogen receptor activation remodels TEAD1 gene expression to alleviate nonalcoholic fatty liver disease

This study shows that activating estrogen receptors in male mice reduces HFD-induced liver steatosis by modulating gene expression and TEAD1, suggesting TEAD1 inhibition as a therapeutic strategy for NAFLD.

CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells

This study investigates on-target genomic effects of CRISPR/Cas9 deletions in human cells, revealing functional DNA disruptions and unexpected consequences.

Analysis at single-cell resolution identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons

The paper analyzes single-cell data to show stable codon and anticodon usage across cell types, with neurons having higher translation efficiency due to increased tRNAAla (AGC) anticodons.

Large-scale identification of RBP-RNA interactions by RAPseq refines essentials of post-transcriptional gene regulation

The paper introduces RAPseq, a method for large-scale profiling of RBP-RNA interactions, revealing species-specific binding motifs, cooperative binding, and specialized interactions of non-canonical RBPs.

5'XP sRNA-seq: Efficient Identification of Transcripts With and Without 5' Phosphorylation Reveals Evolutionary Conserved Small RNA

The paper introduces 5XP-seq, a method to identify 5' phosphorylated and non-phosphorylated sRNAs, revealing evolutionary conserved small RNA species across species.