Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia
Devashis Mukherjee, Sriram Satyavolu, Asha Thomas, Sarah Cioffi, Yuexin Li, Ernest Ricky Chan, Katherine Wen, Alex Yee-Chen Huang, Mukesh K. Jain, George Dubyak, Lalitha V. Nayak
This study shows that loss of KLF2 in neonatal mice increases mortality from endotoxemia by enhancing NLRP3 inflammasome activity and pro-inflammatory cytokine release, particularly at postnatal day 4.
Journal of Leukocyte Biology · Apr 2, 2025Peer-reviewedImmunology