Ernest Ricky Chan

This study identifies PSMC2 overexpression as a driver of bortezomib resistance in multiple myeloma and shows that combining p97 inhibition with bortezomib overcomes this resistance.

This study shows that loss of KLF2 in neonatal mice increases mortality from endotoxemia by enhancing NLRP3 inflammasome activity and pro-inflammatory cytokine release, particularly at postnatal day 4.

The paper analyzes SARS-CoV-2 sequence diversity in over 360 patients, finding significant underreporting of sequence variation by consensus sequencing methods.