Restoring Cholesterol Efflux in Vascular Smooth Muscle Cells Transitioning into Foam Cells Through Liver X Receptor Activation
Carla Borràs, Noemí Rotllán, Raquel Griñán, David Santos, Arnau Solé, Chen Dong, Qi Zhao, Vicenta Llorente‐Cortés, Marta Mourín, Begoña Soto, Mercedes Camacho, Mireia Tondo, Marina Canyelles, Francisco Blanco‐Vaca, Joan Carles Escolá‐Gil
This study shows that activating LXR enhances cholesterol efflux from vascular smooth muscle cells (VSMCs) transitioning into foam cells, improving reverse cholesterol transport to feces and suggesting LXR agonists and ACAT inhibitors as potential therapies for atherosclerosis.
Biomedicine & Pharmacotherapy · May 21, 2025Peer-reviewedBiochemistry