Kane A. Foster

This paper develops a method to analyze nuclear irregularity in cancer cells using imaging mass cytometry, achieving high accuracy in distinguishing cancerous from non-cancerous nuclei and identifying sub-populations of irregular cells.

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

The paper shows that multiple myeloma progression is linked to increased CD56bright bone marrow resident NK cells, which may contribute to immune evasion.