This paper introduces X-ray phase contrast imaging for high-resolution, high-contrast analysis of human fetal tissues, demonstrating its potential for studying development and malformations.

bioRxiv · Apr 18, 2023 · PreprintDevelopmental Biology

Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models

Matthieu Chourrout, Hugo Rositi, Elodie Ong, Violaine Hubert, Alexandre Paccalet, Louis Foucault, Awen Autret, Barbara Fayard C, Cécile Olivier, Radu I. Bolbos, Françoise Peyrin, Claire Crola Da Silva, David Meyronet, Olivier Raineteau, Hélène Elleaume, , Marlène Wiart

This paper introduces an X-ray phase-contrast tomography method to map myelin in whole rodent brains without staining, showing it can detect and quantify white-matter injuries in disease models.

Biomedical Optics Express · Nov 5, 2021Peer-reviewedNeuroscience

Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer's disease models

Matthieu Chourrout, Margaux Roux, Carlie Boisvert, Coralie Gislard, David Legland, Ignacio Arganda‐Carreras, Cécile Olivier, Françoise Peyrin, Hervé Boutin, Nicolas Rama, Thierry Baron, David Meyronet, Emmanuel Brun, Hugo Rositi, Marlène Wiart, Fabien Chauveau

This paper introduces a method using X-ray phase-contrast tomography to analyze 3D morphology of amyloid-β plaques in Alzheimer's disease mouse models and identifies differences in plaque characteristics across strains.

Biomedical Optics Express · Oct 18, 2021Peer-reviewedNeuroscience