Sandrine Humbert

HUNTINGTON DISEASE ALTERS THE PATTERNING OF NEOCORTICAL AREA IN MICE

This study shows that Huntington disease in mice causes early embryonic changes in neocortical patterning, leading to postnatal sensorimotor deficits.

Human fetal virtual histology with X-ray phase contrast imaging

This paper introduces X-ray phase contrast imaging for high-resolution, high-contrast analysis of human fetal tissues, demonstrating its potential for studying development and malformations.

Identification of the key role of white matter alteration in the pathogenesis of Huntington's Disease

This study uses longitudinal MRI in a mouse model to show early white matter defects in Huntington's Disease, highlighting their role in pathogenesis and identifying potential biomarkers.

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin

This study shows that Akt phosphorylation of Huntingtin regulates axonal transport of APP and presynaptic levels, affecting synaptic homeostasis and learning.