Author

Gianna T. Busch

University of PennsylvaniaORCID 0000-0002-3328-0083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arjun RajiD· 3 shared Meenhard HerlyniD· 3 shared Naveen JainiD· 2 shared Pavithran T. RavindraniD· 2 shared Ryan H. BoeiD· 2 shared Yogesh GoyaliD· 2 shared Amanpreet KauriD· 1 shared Aoife O’FarrelliD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersSystems Biology

Arjun RajORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintApr 25, 2025

Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

Gianna T. Busch, Ryan H. Boe, Jingxin Li…·Arjun Raj

The paper shows that therapy-resistant cancer cell clones have distinct drug sensitivity profiles, and combinations targeting these subpopulations can effectively eliminate resistant populations.

2 citations

humanbulk RNA-seq

Systems BiologybioRxivPreprintJul 25, 2024

AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance

Jingxin Li, Pavithran T. Ravindran, Aoife O’Farrell…·Arjun Raj

The paper shows melanoma cells develop therapy resistance through AP-1-mediated cellular memories that encode transient gene expression and chromatin changes.

13 citations

humanbulk RNA-seq

Systems BiologybioRxivPreprintDec 8, 2021

Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

Yogesh Goyal, Ian P. Dardani, Gianna T. Busch…·Arjun Raj

The paper shows that resistant fates in cancer cells are predetermined by intrinsic molecular differences, not microenvironmental factors, and can be influenced by drug type and dose.

26 citations

humanscRNA-seq