Author

Kim A. Sharp

University of PennsylvaniaORCID 0000-0002-0338-0382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron L. LuciusiD· 1 shared Ayush SaurabhiD· 1 shared Daniel R. SouthworthiD· 1 shared Gino CingolaniiD· 1 shared James ShorteriD· 1 shared Jaskamaljot Kaur BanwaitiD· 1 shared JiaBei LiniD· 1 shared Stephen C. HarveyiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Aaron L. LuciusORCID

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2 papers

Recent·Most cited

Biased stochastic motor dynamics drive bidirectional, processive translocation by the AAA+ disaggregase Hsp104.

JiaBei Lin, Jaskamaljot Kaur Banwait, Ayush Saurabh, Kim A. Sharp, Daniel R. Southworth, Steve Pressé, Aaron L. Lucius, Yale E. Goldman, James Shorter

This study reveals that Hsp104, an AAA+ ATPase, functions as a bidirectional, processive translocase by switching direction through biased stochastic conformational transitions.

bioRxiv · Aug 11, 2026 · PreprintBiochemistry

Simulations and Electrostatic Analysis Suggest an Active Role for DNA Conformational Changes During Genome Packaging by Bacteriophages

Kim A. Sharp, Xiang-Jun Lu, Gino Cingolani, Stephen C. Harvey

The paper uses computational simulations to show DNA conformational changes driven by electrostatic potential shifts in bacteriophage packaging motors, linking ATP hydrolysis to DNA translocation.

bioRxiv · Mar 30, 2018 · PreprintBiophysics