Yale E. Goldman

This study reveals that Hsp104, an AAA+ ATPase, functions as a bidirectional, processive translocase by switching direction through biased stochastic conformational transitions.

This study identifies nanometer-scale RNA-protein clusters (RPCs) formed by eIF4A with cofactors eIF4B and eIF4G, showing their role in enhancing helicase activity through multivalent RNA interactions.

This paper investigates the HCM mutation M493I in β-cardiac myosin, showing it disrupts the super-relaxed state, slows ADP release, and enhances actin attachment and force production, leading to hypercontractility.

This study uses single-molecule techniques to analyze tRNA selection during eukaryotic translation, revealing faster near-cognate sampling and a negative correlation between near-cognate concentration and tRNA accommodation efficiency.

This paper identifies a novel epitope (S2Tag) recognized by an antibody that effectively tethers coiled-coil proteins, demonstrating its utility in studying β-cardiac myosin mechanics and disease mutations.

This study identifies cyclic peptides that suppress nonsense mutations in yeast, showing high readthrough activity and low cytotoxicity, suggesting potential as novel therapeutics for genetic diseases.

This study investigates the dynamics between the super-relaxed (SRX) and disordered-relaxed (DRX) states of β-cardiac myosin, showing they are in rapid equilibrium and how mutations and inhibitors affect this balance.

This paper investigates how PTC identity and sequence context affect readthrough efficiency and ataluren's effectiveness, providing insights into patient-specific therapy design.

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.