Author

Marco Novais-Cruz

Oncode InstituteORCID 0000-0002-0361-4855Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

René H. MedemaiD· 2 shared Aditi GnanasekariD· 1 shared Alastair Hamilton· 1 shared Alexander Herrmann· 1 shared Alexander KukaleviD· 1 shared Ana PomboiD· 1 shared Andrea VenturaiD· 1 shared Ann-Sophie Hollinger· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

René H. MedemaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 3, 2025

Megabase-scale detachment of genome-nuclear lamina interactions is required for efficient repair of double stranded breaks

Xabier Vergara, Anna G. Manjón, Marco Novais-Cruz…·René H. Medema

The paper shows that DSBs in LADs cause megabase-scale detachment from the nuclear lamina, which is necessary for efficient repair.

2 citations

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 15, 2025

Extrachromosomal DNA micronucleation constrains tumour fitness andimproves patient survival

Lotte Brückner, Robin Xu, Jun Tang…·Anton George Henssen

This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.

7 citations

humanexperimental assay

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