Author

Vaishnavi Divya Nagarajan

University of KansasORCID 0000-0002-0368-129XUnclaimed ORCID profile · follow to get notified of new preprints

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

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Brian D. AckleyiD· 1 shared Caitlin L. Libowitz· 1 shared Michael S. WolfeiD· 1 shared

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2026-2026 · peak 1/yr

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Recent·Most cited

A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide

Vaishnavi Divya Nagarajan, Caitlin L. Libowitz, Brian D. Ackley, Michael S. Wolfe

This paper shows that synaptic loss in a C. elegans model of familial Alzheimer's disease is caused by stalled gamma-secretase enzyme-substrate complexes, not amyloid beta peptides or reduced enzyme activity.

Neurobiology of Disease · Jan 10, 2026Peer-reviewedNeuroscience