Author

Michael S. Wolfe

University of KansasORCID 0000-0002-2923-3436Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brian D. AckleyiD· 1 shared Caitlin L. Libowitz· 1 shared Vaishnavi Divya NagarajaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperNeuroscience

Brian D. AckleyORCID

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1 paper

Recent·Most cited

NeuroscienceNeurobiology of DiseasePeer-reviewedJan 10, 2026

A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide

Vaishnavi Divya Nagarajan, Caitlin L. Libowitz, Brian D. Ackley, Michael S. Wolfe

This paper shows that synaptic loss in a C. elegans model of familial Alzheimer's disease is caused by stalled gamma-secretase enzyme-substrate complexes, not amyloid beta peptides or reduced enzyme activity.

1 citation

C. elegansexperimental assay