Brian D. Ackley

This study investigates the tissue and cellular tropism of Drosophila innubila Nudivirus in cultured cells and infected hosts, finding that the virus localizes to the nucleus in cells and the gut and reproductive tissues in hosts.

This paper shows that synaptic loss in a C. elegans model of familial Alzheimer's disease is caused by stalled gamma-secretase enzyme-substrate complexes, not amyloid beta peptides or reduced enzyme activity.

This study shows that Alzheimer's mutations stabilize harmful enzyme-substrate complexes in gamma-secretase, leading to synaptic loss rather than the released Aβ peptides being the primary cause.

The paper compares gene expression responses to microbial infection in two C. elegans isolates, finding isolate- and pathogen-specific differences in gene expression.

The paper compares transcriptional responses to bacterial pathogens in Drosophila and Caenorhabditis, finding conserved and divergent gene expression patterns.

The paper shows that EXC-2 and IFA-4 intermediate filaments maintain the structure of C. elegans excretory canals by preventing swelling and guiding tubule growth.

This study shows syndecan regulates Wnt-dependent axon guidance in C. elegans by modulating EGL-20/Wnt ligand activity and interacting with downstream components like lin-17/Frizzled and bar-1/β-catenin.