Siqi Zhao

The paper introduces scMPRA, a single-cell assay to measure cis-regulatory activity across cell types, showing it detects cell-type specific effects of genetic variants in retinas.

The paper introduces SARGENT, a method to measure gene expression noise and mean expression across the genome, finding correlations between noise and histone modifications, and linking extrinsic noise to cell sub-states.

The paper measures how gene promoters and chromatin environments independently affect expression noise across different chromosomal locations.