Connie A. Myers

The paper shows that cis-regulatory codes in retinal cell classes are highly conserved across vertebrates despite extensive enhancer turnover.

The paper uses active learning to improve models of enhancer and silencer activities in mouse retina, achieving better discrimination between functionally distinct TF binding sites.

The paper shows CRX binding sites can act as enhancers or silencers based on sequence context, with negative homotypic interactions causing silencing and positive interactions or other TFBSs overcoming this.

The paper introduces scMPRA, a single-cell assay to measure cis-regulatory activity across cell types, showing it detects cell-type specific effects of genetic variants in retinas.

The paper identifies a candidate causal variant, rs77910749, that links enhanced cognitive performance with increased bipolar disorder risk through its effect on POU3F2 expression and amygdala function.

The paper identifies sequence features that distinguish enhancers from silencers in mouse photoreceptors by analyzing TF motifs and information content.

The paper identifies cis-regulatory features distinguishing retinal photoreceptors and bipolar cells, showing motif partitioning drove transcriptome divergence.