Michael A. White

The paper shows that splicing inhibition autoregulates three yeast ribosomal protein genes by inserting introns into GFP and observing repression.

The paper shows that RPL7B autoregulation occurs through inhibition of splicing by Rpl7 protein binding to a conserved structure in the first intron.

This study identifies functional non-coding variants associated with orofacial cleft by combining GWAS, reporter assays, and stem cell modeling.

The paper uses active learning to improve models of enhancer and silencer activities in mouse retina, achieving better discrimination between functionally distinct TF binding sites.

The paper performs a deep mutational scan of CRX variants to classify clinical variants and reveals biochemical properties of the transcriptional effector domain.

The paper examines how different pathogenic variants in the CRX gene affect cis-regulatory elements in photoreceptors, showing overlapping enhancer effects and distinct silencer impacts.

The paper shows CRX binding sites can act as enhancers or silencers based on sequence context, with negative homotypic interactions causing silencing and positive interactions or other TFBSs overcoming this.

The paper introduces scMPRA, a single-cell assay to measure cis-regulatory activity across cell types, showing it detects cell-type specific effects of genetic variants in retinas.

The paper identifies sequence features that distinguish enhancers from silencers in mouse photoreceptors by analyzing TF motifs and information content.

The paper identifies autoregulation in yeast ribosomal proteins by overexpressing genes and observing repression of GFP-fused versions, finding 21 genes with at least three-fold repression.